At MartiDerm, we are thrilled to share that Advanced Renew has been awarded the prize for best night serum by CLARA magazine in the “Best Next-Generation Night Serum” category of its 2025 Beauty Awards.
This award highlights its innovation, efficacy and high tolerance, making it a benchmark for renewal dermocosmetics.
The best night serum for renewed skin
Advanced Renew is a night serum with triple-action regenerative technology that reduces visible wrinkles and prevents future wrinkles. This renewal serum is developed with state-of-the-art active ingredients that stimulate skin renewal, improve firmness and deeply moisturise.
Its main ingredients include:
- ● ChronoRenew Peptides: Innovative renewal peptide complex which acts on static wrinkles that are already visible, as well as on dynamic and gravitational wrinkles.
- ● Alpha and poly hydroxy acids: Promote skin renewal and improve skin texture.
- ● Ectoin: Deeply moisturises and protects against external damage.
- ● Proteum 89+: MartiDerm's exclusive proteoglycan that moisturises, tones and improves skin firmness.
Clinical efficacy on all types of wrinkles
In vivo clinical studies carried out with Advanced Renew demonstrate its ability to act not only on visible signs of aging, but also on overall skin quality, gradually improving its appearance and structure.
After applying it every night for just eight weeks, significant reductions were observed in all types of wrinkles:
- ● Up to 53% reduction in static wrinkles ¹
- ● Up to 32% reduction in dynamic wrinkles ¹
- ● Up to 57% reduction in gravitational wrinkles ²
Improvements in skin texture and smoothness, as well as excellent dermatological tolerance were also observed in 100% of participants, with no adaptation period required. From the first night, skin feels brighter, firmer, more moisturised and even.
¹ Anti-wrinkle efficacy under dermatological control. Maximum values. Ref: 33500125.A-B
² Anti-wrinkle efficacy under dermatological control. Redensifying effect to reduce the appearance of gravitational wrinkles. Average maximum improvement. Ref: 33500125.A-B
What our PhD Medical Director says about Advanced Renew
Innovation and research have been key to the development of Advanced Renew. In an interview for CLARA magazine, Tamara Martínez, PhD Medical Director of MartiDerm, shares the key factors that make this serum a benchmark for the night serum category:
What does this night serum provide?
This serum is not only innovative, but it also boasts a 360⁰ renewal effect that is very well tolerated, even on sensitive skin. Advanced Renew boosts cell renewal during rest hours. At night, skin enters its repair stage, and Advanced Renew strengthens this process by acting in synergy on cell renewal mechanisms. Thanks to its triple-action regenerative technology, it helps to achieve smoother, brighter and more revitalised skin from the first application.
According to clinical studies, which of the product’s qualities stand out?
Like all MartiDerm products, Advanced Renew is backed by clinical studies that demonstrate its efficacy and tolerance. In this case, it is the first serum to be tested on three type of wrinkles: static, dynamic or expression, and gravitational wrinkles. This serum has been proven to increase collagen synthesis in vitro, which results in firmer skin with a smooth and even texture. A reduction in static and dynamic wrinkles has also been proven thanks to assessments performed with 3D technology, and a redensifying effect that improves skin structure has also been observed, which slows down the appearance of deeper (gravitational) wrinkles by means of skin ultrasound scanning. This unprecedented efficacy is combined with its high tolerance on even the most sensitive skin. These findings confirm that Advanced Renew is effective and safe, and it also sets a new standard in renewal cosmetics.
It uses triple-action regenerative technology. What does that mean?
Its triple-action regenerative technology is based on the selection of ingredients that act on three levels. Firstly, surface renewal thanks to glycolic and lactobionic acid, which gently exfoliate without irritation. Then, deep cell stimulation with ChronoRenew Peptides, which activate regeneration in both the epidermis and dermis. And lastly, protection and moisturisation with ectoine and Proteum 89+, which reinforce the skin barrier and improve firmness.
This synergy makes it possible to improve the three types of wrinkles (static, dynamic and gravitational).
How soon will results start to be noticed?
Its triple-action regenerative technology is based on the selection of ingredients that act on three levels. Firstly, surface renewal thanks to glycolic and lactobionic acid, which gently exfoliate without irritation. Then, deep cell stimulation with ChronoRenew Peptides, which activate regeneration in both the epidermis and dermis. And lastly, protection and moisturisation with ectoine and Proteum 89+, which reinforce the skin barrier and improve firmness.
This synergy makes it possible to improve the three types of wrinkles (static, dynamic and gravitational).
After the first night, skin wakes up looking brighter and more moisturised. In two weeks, 80% of users see smoother and more even skin. And in four weeks, 88% report other results, such as a reduction in expression lines and wrinkles.
MartiDerm: Science that transforms skin
At MartiDerm, we have been combining science, pharmaceutical expertise and active listening to real skin needs for decades. Advanced Renew symbolises this philosophy: a formula that boosts cell renewal at night in order to achieve smoother, firmer and visibly renewed skin.
This award from CLARA magazine for best night serum is not only cause for satisfaction, but it is also a driving force to keep developing effective and safe solutions that are adapted to each skin type.